course aims in Estonian
Molekulaarbioloogilise mõtlemise arendamine geeniekspressiooni-keskse vaatlemisega läbi kromatiini remodelleerimise, transkriptsiooni, mRNA splaissingu, RNA interferentsi ja translatsiooni
course aims in English
Molecular biology-oriented approach to gene regulation through chromatin remodelling, transcription, RNA interference, mRNA splicing and translation
learning outcomes in the course in Est.
Saadakse aru ja seletatakse põhilisi geeniregulatsiooni etappe alates kromatiini remodelleerimisest kuni translatsioonini
learning outcomes in the course in Eng.
Understanding and explanation of the major aspects of gene regulation in the flow of genetic information from transcription to translation
brief description of the course in Estonian
Käsitletakse järgmisi teemasid: Geeni definieerimine (kaasaegne aspekt); genoomi struktuur, mobiilsus ja ebastabiilsus; kaasaegne geeniekspressiooni teooria; kromatiini remodelleerimine, geeni regulaatorelemendid; transkriptsioon ja kotranskriptsiooniline alternatiivne splaissing, geenivaigistamine, mRNA kvaliteedikontroll (NMD ja NSD), mittekodeeriva RNA roll, mRNA translatsioon tuumas ja tsütoplasmas, translatsioon ja haigus, ribosoomi gümnastika.
brief description of the course in English
The following topics are described: Gene definition (contemporary view); genome structure, mobility and instability; comtemporary theory of gene expession, chromatin remodeling, gene regulatory elements, transcription and alternative splicing, gene silencing, mRNA quality control (NMD and NSD), non-coding RNA regulation, mRNA translation in the nucleus and cytoplasm, translation and disease, ribosome gymnastics.
type of assessment in Estonian
20 küsimusega arvestus
type of assessment in English
Assessment with 20 short questions
independent study in Estonian
Loengus antud artiklite lugemine.
independent study in English
Scientific papers delivered during the course of study.
study literature
Alberts et al Molecular Biology of the Cell (basic); Science, Nature, Cell, Trends in Genetics etc. H. Kazazian (University of Pennsylvania), N. Proudfoot (Oxford University), G. Ast (TelAviv University), J. Dekker (University of Massachusetts). G. Faulkner (University of Queensland) recently published articles
study forms and load
daytime study: weekly hours
4.0
session-based study work load (in a semester):