Immunoloogia põhialuste kinnistamine ja molekulaarsete
mehhanismide omandamine. Arusaamine kaasaegse molekulaarse immunoloogia põhiprintsiipidest ja omandatud teadmiste rakendamine seminari ettekandes ning immunoloogia II praktikumis püstitatud ülesannete lahendamisel.

The course will refresh and extend your knowledge about cells, receptors and effectors of immunity. You will also learn about immune regulation of responses during infections, inflammatory and autoimmune diseases. Mechanisms of inflammatory response and resilience to steady state will be reviewed along with some clinical aspects that are connected. You will learn about generation of immunological memory, location and activation of memory cells in the organism; memory response and ageing. In the combined practical course you will learn to isolate immunological tissues and cells from the mouse, after checking the included videos

Üliõpilane tunneb kaasaegse molekulaarse immunoloogia põhiprintsiipe ja on võimeline neid rakendama laboris.

At the end of this course the learner will be able to:
- Outline the role of the immune system in the human body;
- Describe the function of immune regulation of responses during infections, inflammatory and autoimmune diseases;
- identify the symptoms of the inflammatory response and explain their causes;
- Define the role of inflammatory response and resilience to steady state
- Describe the location and activation of memory cells and explain how immunological memory is generated (regarding ageing)
- Isolate and distinguish different immunological tissues and cells
- Characterize and the fundamental mechanisms underlying immunologic disease and associate these mechanisms with strategies for therapeutic modulation of the immune system.
- Discuss the fundamental mechanisms underlying protective immune responses, and discuss the recent advances and emerging themes in immunology research.
- Analyze the scientific literature reporting immunologic advances and use the aquired knowledges in solving respctive problems.

Immunoloogia II kursuse käigus ôpite eraldama immunoloogilisi kudesid ja rakke ning neid vaatlema ja analüüsima läbivoolu tsütomeetrias (FACS). Ôpite tundma immuunsüsteemi regulatsiooni: võrdlema immuunsüsteemi aktivatsiooni selle tasakaaluga (infektsioonide, pôletike vôi autoimmuunsete attakide käigus) ning analüüsima nende protsesside erinevusi. Samuti ôpite tundma innate lümfotsüüte, immunoloogiliste mälurakkude genereerimist, paiknemist organismis, nende aktivatsiooniks vajalikke eelduseid ning seost organismi vanusega.

Main subjects.
Cells and organs of the immune system. Lymph.
Adaptive and innate lymphoid cells.
Immunregulation. Viral and bacterial infections
Cytokines
Inflammation
Immunological memory
Autoimmunity: basic concepts. Selected examples of autoimmune disorders: Multiple sclerosis, Experimental autoimmune encephalomyelitis (EAE)
Tumor immunology and tolerance
Learning modules:
Presentation slides and test questions, that cover each of the 8 topics. Students are expected to log in to the course every day and to work at least 3 hours
Additional reading: Recommended text books and links to their available contents will be found in the Bibliography.
Seminars will be delivered as learning modules and made available in a sequential manner throughout the course. Students will be encouraged to read the assigned module requirements and the materials made available. At the end of the course there will be a seminar where participants of the course have presentations on given topics.
Practical course. The goal of this practical course is to introduce students to state of the art experimental approaches used in investigating the immune response of a research subject. In the combined practical course students will learn to isolate immunological tissues and cells from the mouse, after checking the included videos
Small groups consisting of 2-3 students will be assigned to each practical course that includes a learning plan with objectives, tasks and result presentation. A report of the practical course has to be written, submitted to the supervisor

Eksam

Final grade is based upon final examination score (0 to 80) adjusted with student’s performance during seminars (0 to 10) and practical course (0 to 10).
Evaluation questionnaire:
At the end of the course a questionnaire consisting of 10 multiple choice questions for each topic related to students compliance and satisfaction with e-learning will be made available

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1) Kuby Immunology 6th 2006, By Thomas J. Kindt, Richard A. Goldsby, Barbara Anne Osborne, Janis Kuby - W.H. Freeman (2006) - Paperback - 574 pages - ISBN 1429202114
2) Richard Coico Immunology: A Short Course 2009, 391p Willey-Blackwell
3) Fundamental Immunology 6th Revised edition
William E. Paul; Pub. Date: 01-May-2008, Hardback, Publisher: Lippincott Williams and Wilkins. ISBN-13: 9780781765190, ISBN-10: 0781765196

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